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. hydroxyurea, methotrexate. renal failure,. The effective dose per kg of body weight may be determined for example by chemosensitive assays utilizing cells.Chemo Meds; Chemo Meds Oct 27, 2014. (after at least 6 mo. of treatment with a total cumulative dose >2 g) Renal/Hepatic. if signs of failure appear, when dose.

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